Ad
related to: pten phosphatase function
Search results
Results from the WOW.Com Content Network
The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right [5]) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the enzymatic function of the protein, while the C2 domain binds the phospholipid membrane.
PTEN also refers to a member of the class, phosphatase and tensin homolog. [ citation needed ] This enzyme participates in 10 metabolic pathways : inositol phosphate metabolism , phosphatidylinositol signaling system , p53 signaling pathway , focal adhesion , tight junction , endometrial cancer , glioma , prostate cancer , melanoma , and small ...
Many phosphatases have yet to be discovered, and for numerous known phosphatases, a substrate has yet to be identified. However, among well-studied phosphatase/kinase pairs, phosphatases exhibit greater variety than their kinase counterparts in both form and function; this may result from the lesser degree of conservation among phosphatases. [4]
PtdIns(3,4,5)P 3 is dephosphorylated by the phosphatase PTEN on the 3 position, generating PI(4,5)P 2, and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring, producing PI(3,4)P 2. [5] The PH domain in a number of proteins binds to PtdIns(3,4,5)P 3. Such proteins include Akt/PKB, [6] PDPK1, [7] Btk1, and ARNO ...
Dual-specificity phosphatase (DUSP; DSP) is a form of phosphatase that can act upon tyrosine or serine/threonine residues. [1] There are several families of dual-specificity phosphatase enzymes in mammals. All share a similar catalytic mechanism, by which a conserved cysteine residue forms a covalent intermediate with the phosphate group to be ...
Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P 3, at the 5' position of the inositol ring. [22] The PI3K-Akt pathway regulates PTEN levels by affecting its transcription and activity.
It is involved in cognitive processes such as memory, learning, and executive functions. It influences mood and emotional well-being, acting on serotonin and other neurotransmitter systems.
2. Other functions and targets. RhoA-GTP stimulates the phospholipid phosphatase activity of PTEN (phosphatase and tensin homologue), a human tumor suppressor protein. This stimulation seems to depend on ROCK. [8] [9] In this way, PTEN is important to prevent uncontrolled cell division as is exhibited in cancer cells.
Ad
related to: pten phosphatase function