Search results
Results from the WOW.Com Content Network
NSAIDs reduce kidney blood flow and thereby decrease the efficacy of diuretics, and inhibit the elimination of lithium and methotrexate. [113] NSAIDs cause decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin. [113]
While chronic life stress was once believed to be the main cause of ulcers, this is no longer the case. [27] It is, however, still occasionally believed to play a role. [27] This may be due to the well-documented effects of stress on gastric physiology, increasing the risk in those with other causes, such as H. pylori or NSAID use. [28]
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins , endogenous signaling molecules known to cause these symptoms.
Long-term use of NSAIDs can cause gastric erosions, which can become stomach ulcers and in extreme cases can cause severe haemorrhage, resulting in death. The risk of death as a result of GI bleeding caused by the use of NSAIDs is 1 in 12,000 for adults aged 16–45. [5] The risk increases almost twentyfold for those over 75. [5]
Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. [1] There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow in stomach and kidney, regulating the contraction of involuntary muscles and blood vessels, and act as a mediator of inflammation and pain.
As with other NSAIDs, ibuprofen has been reported to be a photosensitizing agent, [38] but it is considered a weak photosensitizing agent compared to other members of the 2-arylpropionic acid class. Like other NSAIDs, ibuprofen is an extremely rare cause of the autoimmune diseases Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis.
Zollinger-Ellison syndrome (ZES) is caused by a gastrinoma, which is a gastrin-producing tumor that causes gastric acid hypersecretion. [11] The main clinical manifestations of ZES are peptic ulcers and diarrhea. [12] The initial diagnostic test for ZES is a fasting serum gastrin level when antisecretory medications are stopped. If the gastrin ...
This pharmacology -related article is a stub. You can help Wikipedia by expanding it.