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Mithradates the VI, reputed for intentionally consuming poison to build immunity. Mithridatism is the practice of protecting oneself against a poison by gradually self-administering non-lethal amounts.
The mixture was reportedly first developed by Rahmat Sulistyo in 1930, as a family recipe. It was first sold to the public at Yogyakarta in 1940 as a premixed jamu, though due to the Indonesian National Revolution the family moved to Semarang and there in 1951 the company Sido Muncul was founded.