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Anorectic. An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. [1] These substances work by affecting the central nervous system or certain neurotransmitters to create a feeling of fullness or reduce the desire to eat. The understanding of anorexiant effects is crucial in the ...
Studies indicate that 5-HT 2C receptor activation will regulate appetite and food consumption, most likely by promoting satiety through appetite suppression by activation of 5-HT 2C. Consequently, selective agents with high affinity for this receptor over 5-HT 2B and 5-HT2 2A are being developed for the treatment of obesity.
In 1959, phentermine first received approval from the United States FDA as an appetite-suppressing drug. [17] Eventually a hydrochloride salt and a resin form became available. [17] Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18]
Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl- N -ethylamphetamine. [8] It is a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [8] Some analogues of fenfluramine include norfenfluramine, benfluorex, flucetorex, and fludorex.
Here’s how these pills work: Appetite suppression. Many weight loss pills work by reducing hunger. ... More than 40 percent of American adults struggle with obesity, and many are turning to ...
Sibutramine is a serotonin–norepinephrine reuptake inhibitor (SNRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%), [22] thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to ...
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