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Meet the Experts: Deena Adimoolam, M.D., board-certified endocrinologist and member of Prevention’s Medical Review Board; Ashita Gupta M.D., M.P.H., E.C.N.U., board-certified integrative ...
A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS. [125] Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is ...
To reduce the risk of developing ketoacidosis (a serious condition where the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medications, recommending they be temporarily stopped before scheduled surgery.
In one systematic review and meta-analysis involving 34 trials with 8,461 participants and 16 intervention arms, researchers found that metformin could significantly reduce body mass index (BMI ...
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
A 2022 review rounded up the results from the STEP (Semaglutide Treatment Effect in People with obesity) clinical trials. These trials looked at how a weekly 2.4-milligram (mg) semaglutide ...
The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections . [5] [6] The most serious side effects include ketoacidosis (high blood levels of acids called ‘ketoacids’), pancreatitis (inflammation of the pancreas), hypersensitivity (allergic reactions) and hypoglycaemia (low blood sugar levels).
A systematic review and network meta-analysis comparing SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors demonstrated that use of SGLT2 inhibitors was associated with a 20% reduction in death compared with placebo or no treatment. [7]