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Osteocytes synthesize sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. [ 15 ] [ 7 ] Sclerostin, the product of the SOST gene, is the first mediator of communication between osteocytes, bone forming osteoblasts and bone resorbing osteoclasts, critical for bone remodeling ...
This is a list of roots, suffixes, and prefixes used in medical terminology, their meanings, and their etymologies.Most of them are combining forms in Neo-Latin and hence international scientific vocabulary.
The periosteum is a membrane that covers the outer surface of all bones, [1] except at the articular surfaces (i.e. the parts within a joint space) of long bones. (At the joints of long bones the bone's outer surface is lined with "articular cartilage", a type of hyaline cartilage.)
Osteocytes do not entirely fill up the canaliculi. The remaining space is known as the periosteocytic space, which is filled with periosteocytic fluid. This fluid contains substances too large to be transported through the gap junctions that connect the osteocytes. In cartilage, the lacunae and hence, the chondrocytes, are isolated from each ...
Sclerostin is a protein that in humans is encoded by the SOST gene. [5] It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.
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Feedback from physical activity maintains bone mass, while feedback from osteocytes limits the size of the bone-forming unit. [32] [33] [34] An important additional mechanism is secretion by osteocytes, buried in the matrix, of sclerostin, a protein that inhibits a pathway that maintains osteoblast activity. Thus, when the osteon reaches a ...