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Osteocytes synthesize sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. [ 16 ] [ 7 ] Sclerostin, the product of the SOST gene, is the first mediator of communication between osteocytes, bone forming osteoblasts and bone resorbing osteoclasts, critical for bone remodeling ...
Osteocytes do not entirely fill up the canaliculi. The remaining space is known as the periosteocytic space, which is filled with periosteocytic fluid. This fluid contains substances too large to be transported through the gap junctions that connect the osteocytes. In cartilage, the lacunae and hence, the chondrocytes, are isolated from each ...
Forms nouns that denote a person who 'feeds on' the first element or part of the word Greek φαγιστής (phagistḗs) eater; see -phagia: Lotophagi-phagy: Forms nouns that denotes 'feeding on' the first element or part of the word Greek φαγία (phagia) eating; see -phagia: hematophagy: phall-phallus: Greek φαλλός (phallós ...
The spaces the cell body of osteocytes occupy within the mineralized collagen type I matrix are known as lacunae, while the osteocyte cell processes occupy channels called canaliculi. The many processes of osteocytes reach out to meet osteoblasts, osteoclasts, bone lining cells, and other osteocytes probably for the purposes of communication. [26]
Active transport is used to move most substances between the blood vessels and the osteocytes. [1] Haversian canals are contained within osteons, which are typically arranged along the long axis of the bone in parallel to the surface. The canals and the surrounding lamellae (8-15) form the functional unit, called a Haversian system, or osteon.
Feedback from physical activity maintains bone mass, while feedback from osteocytes limits the size of the bone-forming unit. [33] [34] [35] An important additional mechanism is secretion by osteocytes, buried in the matrix, of sclerostin, a protein that inhibits a pathway that maintains osteoblast activity. Thus, when the osteon reaches a ...
Osteocytes, the most common cell type within mature cortical bone, actively participate in the growth and maintenance of TCVs through the transfer of mitochondria to endothelial cells. Scanning electron microscopy images have revealed that osteocytes possess numerous dendritic processes with expanded, endfoot-like structures.
The lacuna are situated between the lamellae, and consist of a number of oblong spaces.In an ordinary microscopic section, viewed by transmitted light, they appear as fusiform opaque spots.