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Richard Eastell (born 12 February 1953) is a British medical doctor and Professor of Bone Metabolism at the University of Sheffield. [1] He was born in Shipley (West Yorkshire) and attended the Salt Grammar School, [citation needed] later graduating from the University of Edinburgh in 1977 with an MB ChB and in 1984 with an MD [2] and achieved prominence as an expert in osteoporosis.
To determine an individual's rate of bone turnover, numerous biomarkers are available in the body fluids that can be correlated to this rate, and one such biomarker is NTX. [ 1 ] However, while NTX does fluctuate in a very sensitive manner in line with bone resorption patterns, they are not very specific , in that they may vary spontaneously ...
In the early 2000s, a link between bisphosphonate use and impaired bone physiology was noted. [3] [4] The strong inhibition of osteoclast function precipitated by bisphosphonate therapy can lead to inhibition of normal bone turnover, leading to impaired wound healing following trauma (such as dental surgery) or even spontaneous non-healing bone exposure.
They study found that administering low-dose testosterone undecanoate (TU) at a rate of 20 mg per day to elderly men with low serum testosterone and osteoporosis effectively increases bone mineral density in the lumbar spine and femoral neck, and improves bone turnover, similar to the standard-dose TU (40 mg, per day) treatment.
Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly . [ 3 ]
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Osteogenic loading (OL) is a rehabilitative exercise method with the goal of improving bone density and preventing bone fracture. This may be seen as brief, intensive, resistance exercise for bone health. Osteogenic loading is an outpatient therapy that typically, is used with ambulatory individuals who are able to engage in resistance exercise.
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid [5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. [6] Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. In humans, osteocalcin is encoded by the ...
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