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The first randomized clinical trial evaluating TTFields was published in November, 2014, and evaluated efficacy of this approach in patients with recurrent glioblastoma. [22] This trial was the primary basis for regulatory approval of NovoTTF-100A / Optune in the United States and Europe. [ 22 ]
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]
Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.
This facility was the first to utilize carbon ions clinically, marking a significant advancement in particle therapy for cancer treatment. The therapeutic advantages of carbon ions were recognized earlier, but NIRS was instrumental in establishing its clinical application. [13] [14] C-ion RT uses particles more massive than protons or neutrons ...
Medical research for cancer begins much like research for any disease. In organized studies of new treatments for cancer, the pre-clinical development of drugs, devices, and techniques begins in laboratories, either with isolated cells or in small animals, most commonly rats or mice. In other cases, the proposed treatment for cancer is already ...
These new criteria have been widely adopted and embraced by the regulatory authorities. [1] The mean response rate for new cancer drugs approved by the U.S. Food and Drug Administration, expressed as relative risk, ranges between 1.38x [3] and 2.37x. [4]
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