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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation.It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.
Pronunciation follows convention outside the medical field, in which acronyms are generally pronounced as if they were a word (JAMA, SIDS), initialisms are generally pronounced as individual letters (DNA, SSRI), and abbreviations generally use the expansion (soln. = "solution", sup. = "superior").
CRP in blood has a half life of less than a day, compared with 4 days for fibrinogen. A continuously elevated CRP content indicates a persistent proinflammatory stimulus in the body. CRP binds to host or bacterial phosphocholine, and the complex activates a group of plasma proteins called complement (Sect. 3.3.2).
This table contains supercentenarian claims with either a known death date or no confirmation for more than two years that they were still alive. Only claims greater than that of Jeanne Calment, who died at the age of 122 years, 164 days, but under 130 years are included. They are listed in order of age as of the date of death or date last ...
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible.
Some factors that indicate a poor prognosis are a QRS greater than 120 milliseconds, a delay in diagnosis, high NYHA class, multiparity, African descent. [ 7 ] Mortality estimates have significant differences depending on the racial group being studied, the geographical location, and the length of follow-up in the study.
~ 1 in 15,000 people a year (> 50 years old) [2] Giant cell arteritis ( GCA ), also called temporal arteritis , is an inflammatory autoimmune disease of large blood vessels . [ 4 ] [ 7 ] Symptoms may include headache , pain over the temples, flu-like symptoms , double vision , and difficulty opening the mouth. [ 3 ]
Norse borrowings are relatively rare in Old English literature, being mostly terms relating to government and administration. The literary standard, however, was based on the West Saxon dialect, away from the main area of Scandinavian influence; the impact of Norse may have been greater in the eastern and northern dialects. Certainly in Middle ...