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Doxylamine is also a potent anticholinergic, meaning that it causes delirum at high doses—i.e., at much higher doses than recommended. [8] (Specifically it is an antagonist of the muscarinic acetylcholine receptors M 1 through M 5.) These sedative and deliriant effects have in some cases led to using the drug recreationally.
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and chlordiazepoxide, are often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for insomnia due to their lesser hangover effect.
A review paper found that long-term use of flurazepam is associated with drug tolerance, drug dependence, rebound insomnia and central nervous system (CNS) related adverse effects. Flurazepam is best used for a short time period and at the lowest possible dose to avoid complications associated with long-term use.
One of the recommended benzodiazepine taper is to reduce the dose by 50% in the first 4 weeks, maintain the dose for 1–2 months, and then reduce the dose by 25% every 2 weeks. [15] Other common side effects of benzodiazepines are drowsiness, dizziness, somnolence and increased risk of ataxia.
Between dinner parties, cookie exchanges and festive cocktails, most people report eating and drinking more than usual during the holidays, gaining on average 1 to 2 pounds of body weight. Now ...
[53] [12] Antihistamine doses, including for dermatological uses and as a sedative/hypnotic for insomnia, are considered to be 3 to 25 mg, [54] [12] although higher doses between 25 and 50 mg and in some cases even up to 150 mg have been used to treat insomnia. [55] At low doses, below 25 mg, doxepin is a pure antihistamine and has more of a ...
Certain types of headaches may be a sign of a more serious condition, such as a brain tumor or aneurysm, especially if the pain is sudden or severe, according to Cohen. "This highlights the ...
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