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Aplastic anemia [2] (AA) [3] is a severe hematologic condition in which the body fails to make blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. [4] Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets. [5] [6]
In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. It is known that more than 150 drugs can cause this type of hemolytic anemia ...
Rarely: aplastic anemia. Inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome Fosfomycin: Monurol, Monuril: Acute cystitis in women: This antibiotic is not recommended for children and 75 and up of age: Inactivates enolpyruvyl transferase, thereby blocking cell wall synthesis Fusidic acid: Fucidin: Metronidazole ...
Over the years, chloramphenicol has been used less in clinical practice due to the risks of toxicity not only to neonates, but also to adults due to the risk of aplastic anemia. [3] [8] [9] Chloramphenicol is now reserved to treat certain severe bacteria infections that were not successfully treated with other antibiotic medications.
Many drugs have been implicated in causing oxidative damage to RBCs, which may cause a hemolytic anemia especially if these drugs are used in individuals with compromised antioxidant mechanisms such as G6PD deficiency or Hemoglobin H disease. Drugs commonly implicated in causing hemolytic anemia in these individuals include [1]: Primaquine; Dapsone
This is a life-threatening disorder that is a characteristic of aplastic anemia. [3] There are also two general causes of cytopenia: autoimmune and refractory. Autoimmune cytopenia is caused by an autoimmune disease when your body produces antibodies to destroy the healthy blood cells.
For example, the antibiotic chloramphenicol can cause pancytopenia in some individuals. [1] Rarely, pancytopenia may have other causes, such as mononucleosis or other viral diseases. Increasingly, HIV is itself a cause of pancytopenia. [2] Familial hemophagocytic syndrome; Aplastic anemia; Gaucher's disease; Metastatic carcinoma of bone ...
The types of anemia treated with drugs are iron-deficiency anemia, thalassemia, aplastic anemia, hemolytic anemia, sickle cell anemia, and pernicious anemia, the most important of them being deficiency and sickle cell anemia with together 60% of market share because of highest prevalence as well as higher treatment costs compared with other ...