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Bebtelovimab is a neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody, isolated from a patient who has recovered from the Coronavirus disease 2019 (COVID-19), directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. [6]
On 16 April 2021, the FDA revoked the emergency use authorization (EUA) that allowed for the investigational monoclonal antibody therapy bamlanivimab, when administered alone, to be used for the treatment of mild-to-moderate COVID-19 in adults and certain pediatric patients. [13] The EUA was issued to Eli Lilly and Co. [3]
Sotrovimab, sold under the brand name Xevudy, is a human neutralizing monoclonal antibody with activity against severe acute respiratory syndrome coronavirus 2, known as SARS-CoV-2. [ 10 ] [ 12 ] [ 13 ] It was developed by GlaxoSmithKline and Vir Biotechnology, Inc. [ 12 ] [ 14 ] Sotrovimab is designed to attach to the spike protein of SARS-CoV-2.
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The principal for obstetric management of COVID-19 include rapid detection, isolation, and testing, profound preventive measures, regular monitoring of fetus as well as of uterine contractions, peculiar case-to-case delivery planning based on severity of symptoms, and appropriate post-natal measures for preventing infection.
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A benefit of casirivimab and imdevimab treatment has not been shown in people hospitalized due to COVID‑19. [9] Monoclonal antibodies, such as casirivimab and imdevimab, may be associated with worse clinical outcomes when administered to hospitalized people with COVID‑19 requiring high flow oxygen or mechanical ventilation. [9]
Pemgarda, made by Invivyd, is an infusion drug approved for use by patients who are immunocompromised to help protect against COVID-19 infection.
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