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Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
Estrace and others Pill and vaginal cream Vaginal cream for vaginal symptoms only; sourced from plants; estradiol is bioidentical until ingested and converted in the liver to estrone: Alora, Climara, Esclim, Estraderm, Vivelle and others Patch Sourced from plants Estrogel Transdermal gel Sourced from plants Estrasorb Topical cream
Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. [ 1 ]
Therapy can take the form of an estrogen pill, skin patch, ring, gel, cream, or spray, and it usually includes a second hormone, progestogen, which can be either progesterone or a synthetic progestin.
In one rodent study, exogenous estrone was administered and increased circulating estradiol levels by about 10-fold; co-administration of a selective 17β-HSD1 inhibitor decreased estradiol levels by about 50%. [70] The ratio of circulating estrone to circulating estradiol is the same at about 5:1 with both oral estradiol and oral estrone ...
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