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The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
Symptoms completely improve in six to eight weeks in 60% to 70% of patients. [33] The combination of therapy and antidepressant medications has been shown to improve the resolution of symptoms and the outcomes of treatment. [33] Suicide is the 8th leading cause of death in the United States. [3]
[2] [3] Alternatively, the Montgomery-Åsberg Depression Rating Scale (MADRS) features ten items to be completed for the purpose of assessing the effects of drug therapy, [2] [4] Another scale is the Raskin Depression Rating Scale rating the severity of the patients' symptoms in three areas: verbal reports, behavior, and secondary symptoms of ...
[14] [15] Liothyronine (synthetic T 3) is a type of thyroid hormone and has been associated with improvement in mood and depression symptoms. Benzodiazepines may improve treatment-resistant depression by decreasing the adverse side effects caused by some antidepressants and therefore increasing patient compliance. [16]
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