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  2. Acute liver failure - Wikipedia

    en.wikipedia.org/wiki/Acute_liver_failure

    Common causes for acute liver failure are paracetamol (acetaminophen) overdose, idiosyncratic reaction to medication (e.g. tetracycline, troglitazone), excessive alcohol consumption (severe alcoholic hepatitis), viral hepatitis (hepatitis A or B—it is extremely uncommon in hepatitis C), acute fatty liver of pregnancy, and idiopathic (without ...

  3. Paracetamol poisoning - Wikipedia

    en.wikipedia.org/wiki/Paracetamol_poisoning

    Paracetamol overdose results in more calls to poison control centers in the US than overdose of any other pharmacological substance, accounting for more than 100,000 calls, as well as 56,000 emergency room visits, 2,600 hospitalizations, and 458 deaths due to acute liver failure per year. [95]

  4. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Paracetomol (3D structure) overdose is the most common cause of drug-induced liver disease. Paracetamol also known as acetaminophen, and by the brand names of Tylenol and Panadol, is usually well-tolerated in prescribed dose, but overdose is the most common cause of drug-induced liver disease and acute liver failure worldwide. [12]

  5. Paracetamol - Wikipedia

    en.wikipedia.org/wiki/Paracetamol

    Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.

  6. Liver failure - Wikipedia

    en.wikipedia.org/wiki/Liver_failure

    Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). [1] Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized. [2]

  7. Centrilobular necrosis - Wikipedia

    en.wikipedia.org/wiki/Centrilobular_necrosis

    Centrilobular necrosis (CN) is a nonspecific histopathological observation brought on by hepatotoxins like acetaminophen (paracetamol), [1] thioacetamide, tetrachloride, [2] cardiac hepatopathy due to acute right sided cardiac failure, and congestive hepatic injury in veno-occlusive disease, [3] or hypoxic injury due to ischemia. [2]

  8. King's College Criteria - Wikipedia

    en.wikipedia.org/wiki/King's_College_Criteria

    Amanita phalloides, the death cap mushroom, is a cause of acute liver failure. There are many causes of acute liver failure aside from acetaminophen toxicity; these include viral hepatitis—including hepatitis A (rarely), [4] hepatitis B, [1] hepatitis C (rarely), [5] hepatitis E (especially in pregnant women), [6] Epstein–Barr virus ...

  9. NAPQI - Wikipedia

    en.wikipedia.org/wiki/NAPQI

    NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.

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