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Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. [1]
United States standard drinks of beer, malt liquor, wine, and spirits compared. Each contains about 14 grams or 17.7 ml of ethanol. A standard drink or (in the UK) unit of alcohol is a measure of alcohol consumption representing a fixed amount of pure alcohol.
This BAC roughly corresponds to drinking one gram of pure ethanol. [86] Ethanol is rapidly absorbed through cut or damaged skin, with reports of ethanol intoxication and fatal poisoning. [87] The timing of peak blood concentration varies depends on the type of alcoholic drink: [88] Vodka tonic: 36 ± 10 minutes after consumption; Wine: 54 ± 14 ...
An amphoteric substance is one that can act as an acid or as a base, depending on pH. Water (below) is amphoteric. Water (below) is amphoteric. Another example of an amphoteric molecule is the bicarbonate ion HCO − 3 that is the conjugate base of the carbonic acid molecule H2CO3 in the equilibrium
Another small study on people without diabetes who were overweight or had obesity found that those taking metformin lost between 5.6 and 6.5 percent of their body weight. In contrast, the control ...
In chemistry, an alcohol (from Arabic al-kuḥl 'the kohl'), [2] is a type of organic compound that carries at least one hydroxyl (−OH) functional group bound to a saturated carbon atom. [ 3 ] [ 4 ] Alcohols range from the simple, like methanol and ethanol , to complex, like sugar alcohols and cholesterol .
If you take one metformin tablet a day, it’s usually recommended that you take it with your evening meal. So, for example, the best time to take metformin 500mg once a day would be after your ...
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