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A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: Protein synthesis; Protein storage; Transformation of carbohydrates; Synthesis of cholesterol, bile salts and phospholipids; Detoxification, modification, and excretion of exogenous and endogenous substances
The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). [2] The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules . [ 3 ]
In liver pathology, a ground glass hepatocyte, abbreviated GGH, is a liver parenchymal cell with a flat hazy and uniformly dull appearing cytoplasm on light microscopy. The cytoplasm's granular homogeneous eosinophilic staining is caused by the presence of HBsAg .
The liver parenchyma is the functional tissue of the organ made up of around 80% of the liver volume as hepatocytes. The other main type of liver cells are non-parenchymal. Non-parenchymal cells constitute 40% of the total number of liver cells but only 6.5% of its volume. [11]
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In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue , consisting of portal triads, hepatocytes arranged in linear cords between a capillary network, and a central vein .
Parietal epithelial cell (PEC) Podocyte; Angioblast → Endothelial cell; Mesangial cell. Intraglomerular; Extraglomerular; Juxtaglomerular cell; Macula densa cell; Stromal cell → Interstitial cell → Telocytes; Kidney proximal tubule brush border cell; Kidney distal tubule cell; Connecting tubule cells; α-intercalated cell; β-intercalated ...
The Kupffer cells of liver are phagocytic cells that help in the phagocytosis of dead blood cells and bacteria from the blood. [57] The liver is responsible for immunological effects – the mononuclear phagocyte system of the liver contains many immunologically active cells, acting as a 'sieve' for antigens carried to it via the portal system.