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Erythromelalgia or Mitchell's disease (after Silas Weir Mitchell) is a rare vascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed. There is severe burning pain (in the small fiber sensory nerves) and skin ...
Mary Cadwalader. Relatives. Silas Weir Mitchell (descendant) Silas Weir Mitchell (February 15, 1829 – January 4, 1914) was an American physician, scientist, novelist, and poet. He is considered the father of medical neurology, and he discovered causalgia (complex regional pain syndrome) and erythromelalgia, and pioneered the rest cure.
Named after. Maurice Raynaud. Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which the spasm of small arteries causes episodes of reduced blood flow to end arterioles. [1] Typically the fingers, and, less commonly, the toes, are involved. [1] Rarely, the nose, ears, nipples, or lips are affected. [1]
Acrocyanosis is characterized by peripheral cyanosis: persistent cyanosis of the hands, feet, knees, or face. [4] The extremities often are cold and clammy and may exhibit some swelling (especially in warmer weather). [1][2] The palms and soles exhibit a wide range of sweating from moderately moist to profuse, but all peripheral pulses should ...
Erythromelalgia is a rare clinical disorder causing redness, burning sensation and intense pain in limbs. It is more common to be found in lower limbs than upper limbs. [12] Erythromelalgia initiated from dysfunction of peripheral nerves that thickens the blood vessel walls, resulting in hyperaemic flow in limbs.
Paroxysmal extreme pain disorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing. PEPD often first manifests at the beginning of life, perhaps even in utero, with symptoms persisting throughout life.
Genetic variants. Channelopathies are a group of diseases caused by the dysfunction of ion channel subunits or their interacting proteins. These diseases can be inherited or acquired by other disorders, drugs, or toxins. Mutations in genes encoding ion channels, which impair channel function, are the most common cause of channelopathies. [1]
Red ear syndrome. A red ear syndrome attack, with affected ear on the left. Red ear syndrome (RES) is a rare disorder of unknown etiology which was originally described in 1994. The defining symptom of red ear syndrome is redness of one or both external ears, accompanied by a burning sensation. [1] A variety of treatments have been tried with ...