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Methylketol or 2-methylindole is a mildly toxic and slightly flammable organic compound which occurs as a white solid which turns brown over time. [1] [2] It has chemical formula C 9 H 9 N. [3] Methylketol is used as an intermediate for synthesizing dyes, [4] pigments, [5] optical brighteners, and pharmaceuticals. [6]
A variety of isomers of methyl indole derivatives are known: 1-methylindole; 2-methylindole; skatole (3-methylindole) 4-methylindole; 5-methylindole; 6-methylindole;
Although the synthesis of indole itself is problematic using the Fischer indole synthesis, it is often used to generate indoles substituted in the 2- and/or 3-positions. Indole can still be synthesized, however, using the Fischer indole synthesis by reacting phenylhydrazine with pyruvic acid followed by decarboxylation of the formed indole-2 ...
The Nenitzescu indole synthesis This reaction was named for its discoverer, Costin Nenițescu , who first reported it in 1929. [ 1 ] It can be performed with a number of different combinations of R-groups, which include methyl, methoxy, ethyl, propyl, and H substituents. [ 2 ]
The Smith-modified Madelung synthesis, also called the Smith indole synthesis, was discovered in 1986 by Amos Smith and his research team. This synthesis employs a condensation reaction of organolithium reagents derived from 2-alkyl-N-trimethylsilyl anilines by esters or carboxylic acids to yield substituted indoles. [6]
The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. [1] [2] The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method. The Fischer ...
Skatole or 3-methylindole is an organic compound belonging to the indole family. It occurs naturally in the feces of mammals and birds and is the primary contributor to fecal odor. In low concentrations , it has a flowery smell and is found in several flowers and essential oils , including those of orange blossoms , jasmine , and Ziziphus ...
The Bischler–Möhlau indole synthesis, also often referred to as the Bischler indole synthesis, [1] is a chemical reaction that forms a 2-aryl-indole from an α-bromo-acetophenone and excess aniline; it is named after August Bischler and Richard Möhlau .