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11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone , deoxycortone, and cortexone, [1] [2] is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. [3] It is an active (Na+-retaining ...
The 5α-reduction is a chemical reaction where a functional group attached to the carbon in position 5α of the steroid nucleus is reduced, and a double bond between carbon atoms numbered 4 and 5 (see § Figure 2) in the steroid molecule is replaced to the single bond in a chemical reaction catalyzed by the SRD5A1 enzyme (see examples on the ...
A steroid with modifications away from testosterone in one or both of these areas is commonly referred to as a "prohormone". These enzymatic changes occur with the body's bidirectional enzymes. [3] [4] On October 22, 2004, President Bush signed into law the Anabolic Steroid Control Act of 2004 (118 Stat. 1661). [5]
A commonly consumed example of said precursors are androstenedione and androstenediol, both of which are currently banned substances in the United States. [6] [7] However, several illegal steroids, such as 1-testosterone, are still being produced legally under different chemical names, and the majority have not undergone clinical studies. [6] [8]
Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. [4] It is one of the most abundant circulating steroids in humans. [ 5 ] DHEA is produced in the adrenal glands , [ 6 ] the gonads , and the brain. [ 7 ]
It is on the list of substances prohibited by the World Anti-Doping Agency since it is a detectable metabolite of nandrolone, an anabolic-androgenic steroid (AAS). [1] Consumption of androstendione products contaminated with traces of bolandione may also result in testing positive for nandrolone.
11-Deoxycortisol in mammals has limited glucocorticoid activity, but it is the direct precursor of the major mammalian glucocorticoid, cortisol. [15] As a result, the level of 11-deoxycortisol is measured to diagnose impaired cortisol synthesis, to find out the enzyme deficiency that causes impairment along the pathway to cortisol, and to differentiate adrenal disorders.
This is an accepted version of this page This is the latest accepted revision, reviewed on 12 February 2025. Polycyclic organic compound having sterane as a core structure This article is about the family of polycyclic compounds. For the drugs, also used as performance-enhancing substances, see Anabolic steroid. For the scientific journal, see Steroids (journal). For the Death Grips EP, see ...