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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Used on a short-term basis clinically to treat obesity, some appetite suppressants are also available over-the-counter.Several appetite suppressants are based on a mix of natural ingredients, mostly using green tea as its basis, in combination with other plant extracts, such as fucoxanthin, found naturally in seaweed.
Amfepramone, also known as diethylpropion, is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant. [8] [9] It is used in the short-term management of obesity, along with dietary and lifestyle changes. [8]
Sibutramine is the name of an SNRI based appetite suppressant with use in the treatment of obesity. This was explored in the treatment of depression, but was shown not to be effective. Both sibutramine and venlafaxine are phenethylamine-based. At high doses, both venlafaxine and sibutramine will start producing dopaminergic effects.
Mazindol is used in short-term (i.e., a few weeks) treatment of obesity, in combination with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in people with a body mass index greater than 30, or in those with a body mass index greater than 27 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia.
Tesofensine primarily acts as an appetite suppressant, [8] but possibly also acts by increasing resting energy expenditure. [9] A recent study showed that tesofensine modulates neuronal activity of the lateral hypothalamus, silencing GABAergic neurons, [8] a brain region involve on feeding. Phase II clinical trials for the treatment of obesity ...
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