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They can be designed to specifically target cancer biomarkers, allowing for highly sensitive and accurate detection of cancer cells or molecules associated with cancer. Gene therapy: Nanocarriers, such as lipid nanoparticles or polymer nanoparticles, can deliver therapeutic genes to cancer cells. This approach aims to modify the genetic makeup ...
Reduction Sensitive Nanoparticles are used as nanomedicines for drug delivery. As nanocarriers, RSNP can be loaded with drugs for disease therapeutics. [18] This is commonly observed in the use of tumor and cancer treatments. Cancer cells create reducing environments that are used for RSNP activation.
Drug delivery systems, lipid-[18] or polymer-based nanoparticles, can be designed to improve the pharmacokinetics and biodistribution of the drug. [ 19 ] [ 20 ] [ 21 ] However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients. [ 22 ]
It can be directed to the location of cancer cells with sustained release behavior. Studies have also been done on gold nanoparticle responses to local near-infrared (NIR) light as a stimuli for drug release. In one study, gold nanoparticles functionalized with double-stranded DNA encapsulated with drug molecules, were irradiated with NIR light.
Polymer-drug conjugates are drug molecules held in polymer molecules, which act as the delivery system for the drug. Polymer drugs have passed multidrug resistance (MDR) testing and hence may become a viable treatment for endocrine-related cancers. A cocktail of pendant drugs could be delivered by water-soluble polymer platforms.
When the blood vessels form so rapidly, large fenestrae result that are 100 to 600 nanometers in size, which allows enhanced nanoparticle entry. Further, the poor lymphatic drainage means that the large influx of nanoparticles are rarely leaving, thus, the tumor retains more nanoparticles for successful treatment to take place. [8]
In polymer chemistry, in situ polymerization is a preparation method that occurs "in the polymerization mixture" and is used to develop polymer nanocomposites from nanoparticles. There are numerous unstable oligomers ( molecules ) which must be synthesized in situ (i.e. in the reaction mixture but cannot be isolated on their own) for use in ...
Another cancer related application, though still in mice probing stage, is the use of peptide-coated nanoparticles as activity-based sensors to detect lung cancer. The two main advantages of the use of nanoparticles to detect diseases is that it allows early stage detection, as it can detect tumors the size in the order of millimeters.
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