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[6] [1] The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements. [1] Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby.
Treatment may include dietary changes and folic acid supplements. [1] Dietary changes including eating foods high in folate such as, fruits and green leafy vegetables can help. [1] Prevention is recommended for pregnant women or those who are planning a pregnancy. [1] Folate deficiency is very rare in countries with folic acid fortification ...
A different study corroborates these results and suggests a physiological dose (800 μg) of 5-methyltetrahydrofolate can bypass MTHFR C677T and A1298C isoforms in couples with fertility problems. [16] This treatment with 5-MTHF also avoids un-metabolized folic acid syndrome, which can occur with folic acid intakes of 5 mg per day. [16]
Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease [10] [11] and advanced cancers such as breast and colorectal cancers. [12] It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.
Doses of folic acid over 1 mg are prescription only. The amount of non-prescription prenatal vitamins needed to achieve this dose may have too much vitamin A and lead to fetal toxicity. [2] In addition, the U.S Army currently provides female soldiers with optional prenatal supplements to combat high anemia rates in female soldiers. [10]
raw egg yolk, liver, peanuts, leafy green vegetables B 9: folates, folic acid: water 400 μg/400 μg megaloblastic anemia and deficiency during pregnancy is associated with birth defects (e.g., neural-tube defects) may mask symptoms of vitamin B 12 deficiency; other effects. leafy vegetables, pasta, bread, cereal, liver B 12
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