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This is the primary test done to determine if a patient has anemia. The size, shape and other characteristics of the red blood cells often provide clues to a possible etiology of the anemia.
Anemia must be significant before a person becomes noticeably pale. [1] Additional symptoms may occur depending on the underlying cause. [1] Anemia can be temporary or long term and can range from mild to severe. [6] Anemia can be caused by blood loss, decreased red blood cell production, and increased red blood cell breakdown. [1]
Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]
LID is present in stage 1 and 2, before anemia occurs in stage 3. These first two stages can be interpreted as depletion of iron stores and reduction of effective iron transport. [4] Stage 1 – Characterized by loss of iron stores in the bone marrow while hemoglobin and serum iron levels remain normal. Serum ferritin falls to less than 20 ng/mL.
Nutritional anemia can be caused by a lack of iron, protein, vitamin B12, and other vitamins and minerals that are needed for the formation of hemoglobin. However, Iron deficiency anemia is the most common nutritional disorder. [7] Signs of anemia include cyanosis, jaundice, and easy bruising. [7]
[6]: 141, 262 If the causative antibodies are only active at room temperature, the agglutination can be reversed by heating the blood sample to 37 °C (99 °F). People with warm autoimmune hemolytic anemia may exhibit red cell agglutination that does not resolve on warming. [4]: 88
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