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Such a quadruplex is described as tetramolecular, reflecting the requirement of four separate strands. The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.
RHAU exhibits a unique ATP-dependent guanine-quadruplex (G4) resolvase activity and specificity for its substrate in vitro. [2] [3] RHAU binds G4-nucleic acid with sub-nanomolar affinity and unwinds G4 structures much more efficiently than double-stranded nucleic acid. Consistent with these biochemical observations, RHAU was also identified as ...
DHX36 exhibits a unique ATP-dependent guanine-quadruplex (G4) resolvase activity and specificity for its substrate in vitro. [10] [11] DHX36 displays repetitive unwinding activity as a function of the thermal stability of the G-quadruplex substrate, characteristic of a number of other G-quadruplex resolvases such as the BLM/WRN helicases.
G-quadruplexes, also known as G4 DNA are secondary structures found in nucleic acids that are rich in guanine. [1] These structures are normally located at the telomeres (the ends of the chromosomes). The G-quadruplex can either be parallel or antiparallel depending on the loop configuration, which is a component of the structure.
Hoogsteen pairs have quite different properties from Watson–Crick base pairs.The angle between the two glycosidic bonds (ca. 80° in the A• T pair) is larger and the C1 ′ –C1 ′ distance (ca. 860 pm or 8.6 Å) is smaller than in the regular geometry.
In molecular biology, a guanine tetrad (also known as a G-tetrad or G-quartet) is a structure composed of four guanine bases in a square planar array. [1] [2] They most prominently contribute to the structure of G-quadruplexes, where their hydrogen bonding stabilizes the structure.
G-quadruplex G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine. [4] They are helical in shape and contain guanine tetrads that can form from one, [5] two [6] or four strands. [7] D-loop
Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.