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Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin -regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
TUG releases the GLUT4 containing vesicles (GSVs) in response to insulin stimulation which allows it to move to the plasma membrane. [2] TUG has an N-terminal ubiquitin-like protein domain (UBL1) which in similar proteins appears to participate in protein-protein interactions. [2]
n/a Ensembl ENSG00000125520 n/a UniProt Q9NR83 n/a RefSeq (mRNA) NM_020062 n/a RefSeq (protein) NP_064446 n/a Location (UCSC) Chr 20: 63.74 – 63.74 Mb n/a PubMed search n/a Wikidata View/Edit Human SLC2A4 regulator is a protein that in humans is encoded by the SLC2A4RG gene. The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier ...
Tether containing UBX domain for GLUT4 (TUG) is a protein that in humans is encoded by the ASPSCR1 gene. [ 5 ] [ 6 ] [ 7 ] This gene is a candidate gene for alveolar soft part sarcoma (ASPS).
GLUT4: Expressed in adipose tissues and striated muscle (skeletal muscle and cardiac muscle). Is the insulin-regulated glucose transporter. Responsible for insulin-regulated glucose storage. GLUT14: Expressed in testes: similarity to GLUT3 [12]
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.
A recent siRNA screen identified the involvement of MAP4K4 in the regulation of the glucose transporter GLUT4. [21] The silencing of MAP4K4 in adipocytes elevated the expression of peroxisome proliferator-activated receptor y (PPARy) – a nuclear hormone receptor responsible for the regulation of genes associated with adipocyte differentiation ...
The euplotid nuclear code; The bacterial, archaeal and plant plastid code; The alternative yeast nuclear code; The ascidian mitochondrial code; The alternative flatworm mitochondrial code; The Blepharisma nuclear code [4] The chlorophycean mitochondrial code (none) (none) (none) (none) The trematode mitochondrial code; The Scenedesmus obliquus ...