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  2. Acantholysis - Wikipedia

    en.wikipedia.org/wiki/Acantholysis

    Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .

  3. Tzanck test - Wikipedia

    en.wikipedia.org/wiki/Tzanck_test

    Acantholytic cells with direct immunofluorescence positivity With the use of direct immunofluorescence examination, the specificity of cytology for diagnosing pemphigus can be increased from 43% to 100%. Erythema multiforme, Toxic epidermal necrolysis Apoptotic and necrotic cells, absence of acantholytic cells

  4. Actinic keratosis - Wikipedia

    en.wikipedia.org/wiki/Actinic_keratosis

    Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [4] [5] Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ().

  5. Keratinocyte - Wikipedia

    en.wikipedia.org/wiki/Keratinocyte

    Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [ 1 ] Basal cells in the basal layer ( stratum basale ) of the skin are sometimes referred to as basal keratinocytes . [ 2 ]

  6. Squamous-cell carcinoma - Wikipedia

    en.wikipedia.org/wiki/Squamous-cell_carcinoma

    Cytopathology of squamous-cell carcinoma, nonkeratinizing variant, with typical features. [16] Pap stain. Yet, these findings are overall less specific than for keratinizing squamous-cell carcinoma, and most can be seen in other cancers such as adenocarcinoma as well (which, however, tends to have fine chromatin).

  7. Histopathologic diagnosis of dermatitis - Wikipedia

    en.wikipedia.org/wiki/Histopathologic_diagnosis...

    The dermal papillae between the elongated rete ridges are frequently dome shaped. Necrotic keratinocytes can be observed in the basal layer of the epidermis and at the dermal-epidermal junction. Eosinophilic remnants of anucleate apoptotic basal cells may also be found in the dermis and are referred to as “colloid or civatte bodies”.

  8. Keratosis - Wikipedia

    en.wikipedia.org/wiki/Keratosis

    Keratosis (from kerat-+ -osis) [1] is a growth of keratin on the skin or on mucous membranes stemming from keratinocytes, the prominent cell type in the epidermis. More specifically, it can refer to: actinic keratosis (also known as solar keratosis), a premalignant condition; chronic scar keratosis; hydrocarbon keratosis

  9. Keratohyalin - Wikipedia

    en.wikipedia.org/wiki/Keratohyalin

    Keratohyalin is a protein structure found in cytoplasmic granules of the keratinocytes in the stratum granulosum of the epidermis.Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, [1] loricrin [2] and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope.