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2C-iBu is a highly potent and robustly efficacious serotonin 5-HT 2A receptor agonist. [4] Its EC 50 Tooltip half-maximal effective concentration values are 1.3 nM for calcium mobilization and 57.5 nM for β-arrestin-2 recruitment, whereas its E max Tooltip maximal efficacy values are 103% for calcium mobilization and 77% for β-arrestin-2 recruitment relative to serotonin. [4]
Abuse of the drug or other substances may lead to severe psychological or physical dependence. The complete list of Schedule II substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.
2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.
At least some 2C drugs, such as 2C-D and 2C-E, produce hyperlocomotion at lower doses in rodents. [6] All 2C drugs produce hypolocomotion at higher doses in rodents. [6] 2C drugs, including 2C-C, 2C-D, 2C-E, and 2C-I, substitute partially to fully for psychedelics like DOM, DMT, and LSD and/or for the entactogen MDMA in rodent drug ...
2,5-Dimethoxy-4-cyanoamphetamine (DOCN) is a serotonergic drug of the phenethylamine, amphetamine, and DOx families. [1] [2] [3] It is a DOx derivative with a cyano group (–C≡N) at the 4 position of the molecule. [1] [2] [3] The drug shows much lower affinities for the serotonin 5-HT 2 receptors than other DOx drugs.
2C-C is a psychedelic drug of the 2C family.It was first synthesized by Alexander Shulgin, sometimes used as an entheogen.In his book PiHKAL (Phenethylamines i Have Known And Loved), Shulgin lists the dosage range as 20–40 mg. 2C-C is usually taken orally, but may also be insufflated.
Controlled Substances; Long title: An Act to amend the Public Health Service Act and other laws to provide increased research into, and prevention of, drug abuse and drug dependence; to provide for treatment and rehabilitation of drug abusers and drug dependent persons; and to strengthen existing law enforcement authority in the field of drug abuse.
2C-T-2 is a psychedelic and entactogenic phenethylamine of the 2C family. [1] It was first synthesized in 1981 by Alexander Shulgin, and rated by him as one of the "magical half-dozen" most important psychedelic phenethylamine compounds. [2] [3] The drug has structural and pharmacodynamic properties similar to those of 2C-T-7 ("Blue Mystic").