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In histological terms, the liver consists of a large number of microscopic functional units that work in unison to ensure the overall, proper activity of the entire organ. There are three possible ways of describing one such unit, as given below: Hepatic (classic) lobule; Portal lobule; Liver acinus; Hepatic (classic) lobule
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue, consisting of a portal triad, hepatocytes arranged in linear cords between a capillary network, and a central vein.
Specialized metabolic, secretory, and synthetic functions occur through interactions between blood and hepatocytes (parenchymal liver cells) in units referred to as liver lobules. Nearly 100,000 lobules comprise an adult liver. They are cylindrical structures between 0.8 to 2 mm in diameter.
The internal structure of the liver is made of around 100,000 small hexagonal functional units known as lobules. Each lobule consists of a central vein surrounded by 6 hepatic portal veins and 6 hepatic arteries.
Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools.
Microscopically, the organization of liver parenchyma can be represented by three different schematics: (1) the classic (hepatic) lobule, (2) the portal lobule, and (3) the hepatic acinus. Classic (hepatic) lobules are based upon blood flow.
Histology of the liver - lobules, central veins, hepatocytes, portal triads (hepatic arteries, portal venules, bile ductules), and bile ducts.
In 1833, Kiernan 1 described and illustrated the microscopic anatomy of the liver lobules. This model would later be known as “classic” or “Kiernan” lobule, whereby the basic...
Liver functional unit classification schemes • Lobule first described by Weppler, 1665 • Functional anatomy still not fully known! • Three main models: – Classical lobule – Rappaport’s acinus model – Matsumoto’s primary lobule
Microscopically, the cells of the liver (known as hepatocytes) are arranged into lobules. These are the structural units of the liver. Each anatomical lobule is hexagonal-shaped and is drained by a central vein. At the periphery of the hexagon are three structures collectively known as the portal triad: