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Cryoglobulinemia is a family of rare conditions, called vasculitis. Vasculitis causes irritation and swelling, called inflammation, of the blood vessels. Cryoglobulins are atypical proteins in the blood.
Many cases of mixed cryoglobulinemia are associated with chronic infection with the hepatitis C virus. In rare cases, no underlying cause for the disorder can be identified (essential mixed cryoglobulinemia). Introduction. Cryoglobulinemia involves dysfunction of the immune system.
By contrast, mixed cryoglobulinemia syndrome (MCS) refers to the presence of either type II or type III cryoglobulins circulating in the serum, composed of polyclonal IgG bound to another immunoglobulin with rheumatoid factor activity.
Type II/III (mixed) cryoglobulinemia: The presentation of mixed cryoglobulinemia is commonly associated with underlying symptoms such as arthralgia, fatigue, and myalgia. Also, palpable purpura related to vasculitis or sensory changes due to peripheral neuropathy are common with type II/III.
Essential mixed cryoglobulinemia is often found in people who have a chronic (long-lasting) inflammatory condition, such as an autoimmune disease or hepatitis C. Most people with mixed cryoglobulinemia have a chronic hepatitis C infection.
The mixed cryoglobulinemia syndrome is most often induced by hepatitis C virus (HCV) infection. It can also be associated with autoimmune or lymphoproliferative disorders or, rarely, can be idiopathic. Typically, it follows a chronic, smoldering course.
Essential mixed cryoglobulinemia is a condition caused by abnormal blood proteins called cryoglobulins. Read about essential mixed cryoglobulinemia causes, symptoms (joint pain, swelling, enlarged spleen, skin vasculitis, nerve & kidney disease), prognosis and treatment.
Essential mixed cryoglobulinemia is a rare immune-mediated/autoimmune condition that features cryoglobulins, which are abnormal proteins in the blood that clump together at temperatures below 98.6 degrees Fahrenheit.
Type III mixed cryoglobulinemia (30% to 40% of patients with cryoglo-bulinemia) is characterized by a combination of polyclonal immunoglobulins. Mixed cryoglobulinemia types II and III can be associated with different infectious, immunological and neoplastic diseases.
Mixed cryoglobulinemia (MC), type II and type III, refers to the presence of circulating cryoprecipitable immune complexes in the serum and manifests clinically by a classical triad of purpura, weakness and arthralgias. It is considered to be a rare disorder, but its true prevalence remains unknown.