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Ketamine. Ketamine (2-CL-2’-oxo-PCM) is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects.
Ketamine crystals on a glass plate. K-hole is the feeling of getting a high enough dose of ketamine to experience a state of dissociation.This intense detachment from reality is often a consequence of accidental overconsumption of ketamine; however, some users consciously seek out the k-hole as they find the powerful dissociative effects to be quite pleasurable and enlightening.
Ketamine's rise in the dance culture was most rapid in Hong Kong by the end of the 1990s. [32] Ketamine use as a recreational drug has been implicated in deaths globally, with more than 90 deaths in England and Wales in the years of 2005–2013. [37] They include accidental poisonings, drownings, traffic accidents, and suicides. [37]
And when done under appropriate medical supervision, ketamine is safe. “It is almost impossible to die from an overdose of ketamine alone,” he said, because it doesn’t lower respiration ...
Ketamine, one of the most popular NMDA receptor antagonists. NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N -Methyl- D -aspartate receptor (NMDAR). They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia.
Avra said those using ketamine should test their drugs for the synthetic opioid fentanyl, have Narcan on hand to reverse an opioid overdose in case the drug is contaminated with opioids, and avoid ...
August 15, 2024 at 9:20 AM. Frederick M. Brown/Getty Images. Almost a year after the death of beloved Friends star Matthew Perry—and nine months after an autopsy concluded he had died from the ...
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...