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The hepatocyte is masterful in its ability to secrete numerous different proteins while simultaneously filtering the blood via a ramped-up endocytic system. An important component linking these pathways is that of transcytosis, a mechanism whereby macromolecular cargo is transported from one plasma membrane domain of a cell to the other within ...
The hepatocytes have one (sometimes two) round central-placed nuclei surrounded by cytoplasm rich with organelles that facilitate protein and lipid synthesis and secretion (rough and smooth endoplasmic reticulum, Golgi apparatus and mitochondria).
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading...
The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). It is the main site for the synthesis of lipoproteins, ceruloplasmin, transferrin, complement, and glycoproteins.
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins.
Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively.
Hepatocytes are not simply target cells, but immunological agents in their own right. Hepatocytes are relatively tractable experimentally. In mice, they can be manipulated using a transgenic approach, since the albumin promoter results in highly cell type-specific transgene expression.
Hepatocytes synthesise and secrete bile into a system of tiny bile canaliculi which are present between adjacent hepatocytes. These canaliculi do not have a duct-like structure but consist merely of localised enlargements of the intercellular space between adjacent cells.
Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflammation.
Importantly, while most epithelial cells secrete nascent proteins directionally toward a single lumen, the hepatocyte secretes both proteins and bile concomitantly at its basolateral and apical domains, respectively.