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GAPDH Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI Identifiers Aliases GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase External IDs OMIM: 138400 ; MGI: 5434255 ; HomoloGene: 107053 ; GeneCards: GAPDH ; OMA: GAPDH - orthologs Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,534,512 bp End ...
Housekeeping genes account for majority of the active genes in the genome, and their expression is obviously vital to survival. The housekeeping gene expression levels are fine-tuned to meet the metabolic requirements in various tissues.
The American Cancer Society reports 5-year relative survival rates of over 70% for women with stage 0-III breast cancer with a 5-year relative survival rate close to 100% for women with stage 0 or stage I breast cancer. The 5-year relative survival rate drops to 22% for women with stage IV breast cancer. [3]
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism.Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate.
Patients with a Gene A signature have better percent survival than patients with a Gene B signature. In a 2001 study published in the Proceedings of the National Academy of Sciences, Sørlie et al. [10] further stratified the classifications described by Perou et al. [9] and explored the clinical value of these breast cancer subtypes. The ...
The difference in disease-free survival rates (but not the overall survival rates) between individuals with PABC and ALIC was significant. [31] Further studies with larger numbers of patients are required to further define the features of ALIC and accurately compare its long-term prognosis to PACB as well as other breast cancer tumors. [1]
HRT Atlas allows searching of a complete list of reliable candidate reference genes and transcripts for RT-qPCR normalization in more than 120 human and mouse tissues or cell types. The database also offers some empirically validated primers and predicted modifiers (disease and small molecules) of the expression of these reference genes.
Many of the genes driving the growth at primary site can determine the dissemination and colonization at the ectopic site. [3] [4] [5] Breast cancer is consensually considered genetically and clinically as a heterogeneous disease, in that it reflects the heterogeneity of the normal breast tissue at its origin17873350. [6]