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AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a K i of 1.0 nM at CB 1 and 2.6 nM at CB 2. [6] The 4-methyl functional analog MAM-2201 probably has similar affinities. [original research?] AM-2201 has an EC 50 of 38 nM for human CB 1 receptors, and 58 nM for human CB 2 receptors. [7]
Compared to THC, which is a partial agonist at CB 1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. JWH-018 may cause intense anxiety, agitation, and in rare cases, has been assumed to have been the cause of seizures and convulsions. JWH-018 and analogs of it may present serious dangers to the user when used to excess. [22]
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. [1] These novel psychoactive substances should not be confused with synthetic phytocannabinoids (obtained by chemical synthesis ) or synthetic endocannabinoids from which they ...
MDMB-CHMICA [3] is an indole-based synthetic cannabinoid that is a potent agonist of the CB 1 receptor and has been sold online as a designer drug. [2] [4] [5] [6] While MDMB-CHMICA was initially sold under the name "MMB-CHMINACA", the compound corresponding to this code name (i.e. the isopropyl instead of t-butyl analogue of MDMB-CHMINACA) has been identified on the designer drug market in ...
THJ-2201 is an indazole-based synthetic cannabinoid that presumably acts as a potent agonist of the CB 1 receptor and has been sold online as a designer drug. [1] [2 ...
The FDA on Thursday approved a new class of pain medication that provides an alternative to opioids. It will be sold under the brand name Journavx.
Fentanyl is a synthetic opioid about 50 times more powerful than heroin and 100 times more powerful than morphine. Opioids accounted for about 82,000 U.S. deaths in 2022, ten times the number in ...
MDMB-BINACA (MDMB-BUTINACA) is an indazole-3-carboxamide based synthetic cannabinoid receptor agonist that has been sold as a designer drug, first identified in Sweden in May 2023. It has a similar chemical structure to potent cannabinoid agonists previously reported such as ADB-BUTINACA and MDMB-5'Br-BUTINACA, and is believed to have similar ...
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