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Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
The Massachusetts smallpox epidemic or colonial epidemic was a smallpox outbreak that hit Massachusetts in 1633. [1] Smallpox outbreaks were not confined to 1633 however, and occurred nearly every ten years. [2] Smallpox was caused by two different types of variola viruses: variola major and variola minor. [3]
The most common type of smallpox, ordinary, historically has devastated populations with a 30% death rate. The smallpox virus is transmittable through bodily fluids and materials contaminated with infected materials. Generally, face-to-face contact is required for an individual to contract smallpox as a result of an interaction with another human.
Since 1984, these two labs have been the only ones authorized by the WHO to hold stocks of live smallpox virus. [citation needed] In 1986, the WHO first recommended destruction of all smallpox samples, and later set the date of destruction to be 30 December 1993. This was postponed to 30 June 1999, [5] then again to 30 June 2002.
Together, we ended smallpox, and together we have brought polio to the brink of eradication. American institutions have contributed to and benefited from membership in WHO,” Tedros said.
The 1520s smallpox epidemic spread from Mesoamerica into adjacent maize-growing regions in North America.A population decline in the Columbia Basin, evidenced archaeologically by a sharp regional decline in artifacts and structures in the early 1500s, has been tentatively linked to a spread of this outbreak, but greatly predates any written record in the region.
The clearest description of smallpox from pre-modern times was given in the 9th century by the Persian physician, Muhammad ibn Zakariya ar-Razi, known in the West as "Rhazes", who was the first to differentiate smallpox from measles and chickenpox in his Kitab fi al-jadari wa-al-hasbah (The Book of Smallpox and Measles). [27]
ACAM2000 uses a live, infectious form of the vaccinia virus. Instead of an injection, the Emergent shot is given through a series of small pokes on the skin using a two-pronged needle.