Search results
Results from the WOW.Com Content Network
Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Thiamine, also known as thiamin and vitamin B 1, is a vitamin – an essential micronutrient for humans and animals. [1] [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
This enzyme can be found in a variety of different sources. It can be found in marine organisms, plants, and bacteria. Since thiamine (vitamin B 1) is a very important substance required for metabolic pathways by almost all organisms, it can be very detrimental to introduce Thiaminase to a system. Frequently an organism gains this enzyme by ...
Thiamine pyrophosphate is a cofactor that is present in all living systems, in which it catalyzes several biochemical reactions. Thiamine pyrophosphate is synthesized in the cytosol and is required in the cytosol for the activity of transketolase and in the mitochondria for the activity of pyruvate-, oxoglutarate- and branched chain keto acid ...
Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Within the field of biochemistry, 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) also known as toxopyrimidine together with its mono phosphate (HMP-P) and pyrophosphate (HMP-PP) esters are biogenetic precursors to the important biochemical cofactor thiamine pyrophosphate (TPP), a derivative of thiamine (vitamin B 1).
It serves as a riboswitch [1] [2] that binds thiamine pyrophosphate (TPP) directly and modulates gene expression through a variety of mechanisms in archaea, bacteria and eukaryotes. [ 3 ] [ 4 ] [ 5 ] TPP is the active form of thiamine ( vitamin B 1 ), an essential coenzyme synthesised by coupling of pyrimidine and thiazole moieties in bacteria .
Thiamine monophosphate, also known as ThMP and TMP, is a phosphate ester of thiamine. [1] It is an intermediate from the hydrolysis of thiamine diphosphate to free thiamine by alkaline phosphatase. [2] [3] [4] The conversion of ThMP to thiamine cannot be facilitated by acid hydrolysis. [5]