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The enzyme phospholipase A 2 (EC 3.1.1.4, PLA 2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule: phosphatidylcholine + H 2 O = 1-acylglycerophosphocholine + a carboxylate
18786 Ensembl ENSG00000137055 ENSMUSG00000028577 UniProt Q9Y263 P27612 RefSeq (mRNA) NM_001031689 NM_004253 NM_001321546 NM_172695 RefSeq (protein) NP_001026859 NP_001308475 NP_766283 Location (UCSC) Chr 9: 26.9 – 26.95 Mb Chr 4: 94.46 – 94.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA ...
Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A 2 enzyme that in humans is encoded by the PLA2G7 gene. [5] [6] Lp-PLA 2 is a 45-kDa protein of 441 amino acids. [7] It is one of several PAF acetylhydrolases.
Phospholipase A 2 acts on the intact lecithin molecule and hydrolyzes the fatty acid esterified to the second carbon atom. The resulting products are lysolecithin and a fatty acid. Phospholipase A 2 is an enzyme present in the venom of bees , blennies and viper snakes .
5321 18783 Ensembl ENSG00000116711 ENSMUSG00000056220 UniProt P47712 P47713 RefSeq (mRNA) NM_001311193 NM_024420 NM_008869 NM_001305632 RefSeq (protein) NP_001298122 NP_077734 NP_001292561 NP_032895 Location (UCSC) Chr 1: 186.83 – 186.99 Mb Chr 1: 149.71 – 149.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytosolic phospholipase A 2 is an enzyme that in humans is encoded by ...
Phospholipase A 2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals as well as fish. [7] Sequences of pancreatic PLA 2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is ...
The most common pathway taken to produce PAF is remodeling. The precursor to the remodeling pathway is a phospholipid, which is typically phosphatidylcholine (PC). The fatty acid is removed from the sn-2 position of the three-carbon backbone of the phospholipid by phospholipase A2 (PLA2) to produce the intermediate lyso-PC (LPC).
Calcium-dependent phospholipase A 2 is an enzyme that in humans is encoded by the PLA2G5 gene. [5] [6] [7]This gene is a member of the secretory phospholipase A 2 family. It is located in a tightly-linked cluster of secretory phospholipase A 2 genes on chromosome 1.