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Homeobox (Hox) gene expression in Drosophila melanogaster. Drosophila melanogaster is an important model for understanding body plan generation and evolution. The general principles of Hox gene function and logic elucidated in flies will apply to all bilaterian organisms, including humans. Drosophila, like all insects, has eight Hox genes ...
Homeotic selector gene complexes in the fruit fly Drosophila melanogaster. One of the most commonly studied model organisms in regards to homeotic genes is the fruit fly Drosophila melanogaster. Its homeotic Hox genes occur in either the Antennapedia complex (ANT-C) or the Bithorax complex (BX-C) discovered by Edward B. Lewis. [10]
Drosophila (/ d r ə ˈ s ɒ f ɪ l ə, d r ɒ-, d r oʊ-/ [1] [2]) is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
A June 2001 study by National Human Genome Research Institute comparing the fruit fly and human genome estimated that about 60% of genes are conserved between the two species. [83] About 75% of known human disease genes have a recognizable match in the genome of fruit flies, [ 84 ] and 50% of fly protein sequences have mammalian homologs ...
Drosophila is a genus of flies of the family Drosophilidae. It comprises over 1600 described species, [ 1 ] [ 2 ] but is estimated to have several thousands. [ 3 ] Alfred Sturtevant divided Drosophila into a number of subgenera , including Drosophila , Sophophora , and Dorsilopha .
The best known species of the Drosophilidae is Drosophila melanogaster, within the genus Drosophila, also called the "fruit fly." Drosophila melanogaster is used extensively for studies concerning genetics, development, physiology, ecology and behaviour. Many fundamental biological mechanisms were discovered first in D. melanogaster. [2]
These carry the inserted gene of interest, so can be investigated to determine the phenotype due to the gene of interest. It is important to note that the inserted gene may have damaged the function of one of the host's genes. Several lines of flies are required so comparison can take place and ensure that no additional genes have been knocked out.
The homeotic selector genes were discovered through the genetic analysis of Drosophila over 80 years ago [citation needed].Unusual disturbances were found in the organization of the adult fly, resulting in misplaced limbs, such as legs developing where antennae usually develop or an extra pair of wings developing where halteres should be.