Search results
Results from the WOW.Com Content Network
Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH 2) 4 O. The compound is classified as heterocyclic compound , specifically a cyclic ether . It is a colorless, water- miscible organic liquid with low viscosity .
Additionally, 3-OH THF has been an intermediate to developmental drug substances, such as chemotherapy agents. For example, reaction of phosphorus pentasulfide with 3-hydroxytetrahydrofuran has been used in the synthesis of bis(O,O-di(tetrahydrofuran-3-yl)hydrogen dithiophosphate)platinum(II), a cisplatin analog.
Common ether ligands are diethyl ether and tetrahydrofuran. Common chelating ether ligands include the glymes, dimethoxyethane (dme) and diglyme, and the crown ethers. Being lipophilic, metal-ether complexes often exhibit solubility in organic solvents, a property of interest in synthetic chemistry.
It is produced by polymerization of tetrahydrofuran as well as 1,4-butanediol. The product is commercially available as polymers of low average molecular weights , between 250 and 3000 daltons . In this form it is a white waxy solid that melts between 20 and 30 °C.
Tetrahydrofuran (THF) is the archetypal solvent used for hydroboration. Mechanism and scope. Hydroboration step ... Hexanol synthesis.
The order of addition of the reagents of the Mitsunobu reaction can be important. Typically, one dissolves the alcohol, the carboxylic acid, and triphenylphosphine in tetrahydrofuran or other suitable solvent (e.g. diethyl ether), cool to 0 °C using an ice-bath, slowly add the DEAD dissolved in THF, then stir at room temperature for several hours.
In organic chemistry, Madelung synthesis is a chemical reaction that produces ... (LDA) bases are used, and when tetrahydrofuran is used as the solvent. [2] ...
The Feist–Benary synthesis is a classic way to synthesize furans. The reaction involves alkylation of 1,3-diketones with α-bromoketones followed by dehydration of an intermediate hydroxydihydrofuran. [9] The other traditional route involve the reaction of 1,4-diketones with phosphorus pentoxide (P 2 O 5) in the Paal–Knorr synthesis. [10]