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Myofibroblasts upregulate the expression of fibronectin, collagens, and hyaluronic acid during and after their differentiation from fibroblasts. Among these, the EDA isoform of fibronectin (EDA-FN), and collagen type I ( COL1A1 / COL1A2 ) are typical markers of myofibroblast-dependent synthesis of pro-fibrotic extracellular matrix.
Myofibroblastic cells are plumper with more abundant cytoplasm and more prominent nucleoli; they express smooth muscle marker proteins such as smooth muscle actins, desmin, and caldesmon. [2] The World Health Organization further classified FMTs into four tumor forms based on their varying levels of aggressiveness: benign, intermediate (locally ...
The Function of CAF Markers Name of markers: Functions: α-smooth muscle actin (α-SMA, ACTA2) Marker for myofibroblasts [13] Fibroblast activation protein (FAP) Marker for myofibroblasts [13] Tenascin-C: Regulates adhesion of cancer cells for invasion [14] Periostin: Product of process of tissue repair [15] Neuron glial antigen-2 (NG2, CSPG4)
Cytoglobin expression has been shown to be a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. [2] In murine (rats, mice) liver, reelin expressed by Ito cells has been shown to be a reliable marker in discerning them from other myofibroblasts. [3]
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Retail (Grocery), Health Food Store: Founded: 1978 (47 years ago) ... As of 2024, they have 11 locations in Southern California. [5] References
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Medical imaging may suggest but cannot prove that a tumor is MFB. Mammography, computed tomography scans, and magnetic resonance imaging of mammary [1] [12] and extramammary [1] [13] MFB typically show well-defined and well-circumscribed tumors which in almost all cases have no calcifications; these results suggest that the tumor is not malignant but do not indicate which type it might be.