Search results
Results from the WOW.Com Content Network
Persistence of notochordal cells within the vertebra may cause a pathologic condition: persistent notochordal canal. [17] If the notochord and the nasopharynx do not separate properly during embryonic development, a depression (Tornwaldt bursa) or Tornwaldt cyst may form. [18] The cells are the likely precursors to a rare cancer called chordoma ...
In addition to its role in common cancers, brachyury has been identified as a definitive diagnostic marker, key driver and therapeutic target for chordoma, a rare malignant tumor that arises from remnant notochordal cells lodged in the vertebrae. The evidence regarding brachyury's role in chordoma includes:
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord.The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during ...
Axial mesoderm, or chordamesoderm, is the mesoderm in the embryo that lies along the central axis under the neural tube.. will give rise to notochord; starts as the notochordal process, whose formation finishes at day 20 in humans.
Prior to neurulation, during the migration of epiblastic endoderm cells towards the hypoblastic endoderm, the notochordal process opens into an arch termed the notochordal plate and attaches overlying neuroepithelium of the neural plate. The notochordal plate then serves as an anchor for the neural plate and pushes the two edges of the plate ...
The nucleus pulposus contains loose fibers suspended in a mucoprotein gel. The nucleus of the disc acts as a shock absorber, absorbing the impact of the body's activities and keeping the two vertebrae separated. It is the remnant of the notochord. [2] There is one disc between each pair of vertebrae, except for the first cervical segment, the ...
Homeobox protein notochord (NOTO) is a transcription factor [1] encoded by the gene notochord homeobox (NOTO) located on the short arm of chromosome 2 (2p13.2) in humans (Homo sapiens). [2]
The prechordal cells migrate to the midline to form the notochordal plate. The chordamesoderm is the central region of trunk mesoderm. [4] This forms the notochord, which induces the formation of the neural tube, and establishes the anterior-posterior body axis. The notochord extends beneath the neural tube from the head to the tail.