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Abnormal dreams; Aggression; Anaphylactic shock; Angioedema (indicative of a hypersensitivity reaction); Arthralgia; Ataxia; Blood glucose disturbances; Bronchospasm (indicative of a hypersensitivity reaction)
Bupropion, formerly called amfebutamone, [16] and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is US FDA-approved to treat major depressive disorder, seasonal affective disorder and to support smoking cessation.
Wellbutrin is the brand name for bupropion, a prescription-only antidepressant. Wellbutrin is typically sold in a tablet form that works by increasing the activity of natural chemicals called ...
Wellbutrin and other antidepressants may cause an increase in risk of suicide in young adults. If you start to feel suicidal after using Wellbutrin, it’s important to seek professional medical ...
The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Pharmacology of bupropion and its metabolites Bupropion R,R-Hydroxy bupropion S,S-Hydroxy bupropion Threo-hydro bupropion Erythro-hydro bupropion; Exposure and half-life AUC relative to bupropion [8] [9] 1 23.8 0.6 11.2 2.5 Half-life [10] 1.04 h 19 h 15 h 31 h 22 h Inhibition IC 50 (μM) in human cells, unless noted otherwise DAT, uptake [11] 0 ...
The sustained-release preparation is associated with a seizure incidence of 0.1% at daily dosages of less than 300 mg of bupropion and 0.4% at 300–400 mg. [2] The immediate release preparation is associated with a seizure incidence of 0.4% for dosages below 450 mg; the incidence climbs to 5% for dosages between 450–600 mg per day. [2]
Seizures; Slurred speech; Extrapyramidal symptoms including dyskinesias (acute & delayed) Dystonic reactions; Cogwheel rigidity; Emotional lability; Psychosis; Suicidal ideation; Ataxias; Transient difficulty with recall; Serotonin syndrome; Parkinsonism; Restless leg syndrome; Restlessness; Eye pain; Altered sense of smell; Photophobia ...