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Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. [1]The name of the entity is descriptive of the lesion; ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way ...
Usual ductal hyperplasia with small cells that lack atypia. Histopathology of usual ductal hyperplasia (UDH) on H&E stain and immunohistochemistry.As seen on higher magnification H&E stain at left, it has the usual irregular "slit-like" lumina.
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
Diagram showing ductal carcinoma in situ (DCIS). Date: 30 July 2014 (released by CRUK) Source: Original email from CRUK: Author: Cancer Research UK: Permission (Reusing this file) This image has been released as part of an open knowledge project by Cancer Research UK. If re-used, attribute to Cancer Research UK / Wikimedia Commons
Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a pre-cancerous or non-invasive cancerous lesion of the breast. [ 1 ] [ 2 ] DCIS is classified as Stage 0. [ 3 ] It rarely produces symptoms or a breast lump that can be felt, typically being detected through screening mammography .
In contrast to an artifact of crowded cells, the calcification characteristically extends outside the focal plane, as the background DCIS is blurred in this focus. Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules.
Pathology [ edit ] Although tubular carcinoma has been considered a special-type tumor, [ a ] recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS [ b ] carcinomas with tubular features, depending on the percentage of the lesion that displays ...
Specifically, in LCIS, antibodies targeting the e-cadherin protein (or lack thereof) and p120 catenin proteins are used to differentiate LCIS from DCIS. Due to the fact that LCIS shows lack of e-cadherin expression on cell membranes and subsequent p120 catenin buildup in the cytoplasm, lesions that show positive membrane immunoreactivity for e ...