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  2. List of unsolved problems in chemistry - Wikipedia

    en.wikipedia.org/wiki/List_of_unsolved_problems...

    RNA folding problem: Is it possible to accurately predict the secondary, tertiary and quaternary structure of a polyribonucleic acid sequence based on its sequence and environment? Protein design : Is it possible to design highly active enzymes de novo for any desired reaction?

  3. Histogram - Wikipedia

    en.wikipedia.org/wiki/Histogram

    This histogram shows the number of cases per unit interval as the height of each block, so that the area of each block is equal to the number of people in the survey who fall into its category. The area under the curve represents the total number of cases (124 million). This type of histogram shows absolute numbers, with Q in thousands.

  4. Replication (statistics) - Wikipedia

    en.wikipedia.org/wiki/Replication_(statistics)

    Example of direct replication and conceptual replication There are two main types of replication in statistics. First, there is a type called “exact replication” (also called "direct replication"), which involves repeating the study as closely as possible to the original to see whether the original results can be precisely reproduced. [ 3 ]

  5. Sturges's rule - Wikipedia

    en.wikipedia.org/wiki/Sturges's_rule

    Histogram of 10,000 samples from a Gamma(2,2) distribution. Number of bins suggested by Scott's rule is 61, Doane's rule 21, and Sturges's rule 15. Sturges's rule is not based on any sort of optimisation procedure, like the Freedman–Diaconis rule or Scott's rule. It is simply posited based on the approximation of a normal curve by a binomial ...

  6. Shape of a probability distribution - Wikipedia

    en.wikipedia.org/wiki/Shape_of_a_probability...

    Considerations of the shape of a distribution arise in statistical data analysis, where simple quantitative descriptive statistics and plotting techniques such as histograms can lead on to the selection of a particular family of distributions for modelling purposes. The normal distribution, often called the "bell curve" Exponential distribution

  7. V-optimal histograms - Wikipedia

    en.wikipedia.org/wiki/V-optimal_histograms

    V-optimal histograms are an example of a more "exotic" histogram. V-optimality is a Partition Rule which states that the bucket boundaries are to be placed as to minimize the cumulative weighted variance of the buckets. Implementation of this rule is a complex problem and construction of these histograms is also a complex process.

  8. Entropy estimation - Wikipedia

    en.wikipedia.org/wiki/Entropy_estimation

    A new approach to the problem of entropy evaluation is to compare the expected entropy of a sample of random sequence with the calculated entropy of the sample. The method gives very accurate results, but it is limited to calculations of random sequences modeled as Markov chains of the first order with small values of bias and correlations ...

  9. Histogram matching - Wikipedia

    en.wikipedia.org/wiki/Histogram_matching

    An example of histogram matching In image processing , histogram matching or histogram specification is the transformation of an image so that its histogram matches a specified histogram. [ 1 ] The well-known histogram equalization method is a special case in which the specified histogram is uniformly distributed .