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Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), [1] despite the initial belief that it was biologically inert.
Clozapine (Clozaril), an atypical antipsychotic, fell out of favor due to concerns over drug-induced agranulocytosis. Following research indicating its effectiveness in treatment-resistant schizophrenia and the development of an adverse event monitoring system, clozapine re-emerged as a viable antipsychotic.
Weight gain (particularly prominent with clozapine, olanzapine, quetiapine and zotepine, [38] can be counteracted by starting the drug with metformin [125] [126]) Anticholinergic side-effects (common for olanzapine, clozapine; less likely on risperidone [127]) such as: Blurred vision; Constipation; Dry mouth (although hypersalivation may also ...
(Reuters) -The U.S. Food and Drug Administration said on Thursday its preliminary review did not find evidence that weight-loss drugs such as Novo Nordisk's Wegovy were tied to suicidal thoughts ...
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
Clotiapine (Entumine) is an atypical antipsychotic [2] of the dibenzothiazepine chemical class. [3] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.
The various benzodiazepines differ in their toxicity; temazepam appears most toxic in overdose and when used with other drugs. [ 166 ] [ 167 ] The symptoms of a benzodiazepine overdose may include; drowsiness , slurred speech , nystagmus , hypotension , ataxia , coma, respiratory depression , and cardiorespiratory arrest .