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Midazolam is known to cause respiratory depression. In healthy humans, 0.15 mg/kg of midazolam may cause respiratory depression, which is postulated to be a central nervous system (CNS) effect. [48] When midazolam is administered in combination with fentanyl, the incidence of hypoxemia or apnea becomes more likely. [49]
Midazolam – It is a fast-acting and the most lipophilic of all benzodiazepine and rapidly crosses the blood–brain barrier. It is a gamma-aminobutyric acid (GABA) agonist. [9] Usual doses for midazolam are 1 mg to 2 mg where the older people receive smaller doses and obese people receive higher doses.
The typical anesthesia induction dose is 0.35 grams. Loss of consciousness is induced within 30–45 seconds at the typical dose, while a 5 gram dose (14 times the normal dose) is likely to induce unconsciousness in 10 seconds. A full medical dose of thiopental reaches the brain in about 30 seconds. This induces an unconscious state.
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
The most common standard conscious sedation technique for adults is intravenous sedation using Midazolam. This requires a needle to be put into a vein to deliver the medication; this is known as an IV cannula. [citation needed] Indications: [citation needed] Reduced dental anxiety and phobia; Traumatic or prolonged dental procedures
A first dose can be started at age 9. Research suggests earlier vaccination around 9 years old provides longer immunity, Grella said. It also helps spread out routine childhood vaccines. Adults ...
Midazolam collects in the body's fatty tissues, so a possible complication includes prolonged sedation. As a result, the elderly, the obese, and those with kidney or liver disease are more vulnerable to prolonged sedation with midazolam. Respiratory depression is also associated with midazolam when given in high doses.
The FDA (U.S. Food and Drug Administration) suggests taking Cialis at a maximum as-needed dosage of 10 milligrams no more than once per 72 hours — or a daily dosage of 2.5 milligrams — if you ...