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The three major branches of the trigeminal nerve—the ophthalmic nerve (V 1), the maxillary nerve (V 2) and the mandibular nerve (V 3)—converge on the trigeminal ganglion (also called the semilunar ganglion or gasserian ganglion), located within Meckel's cave and containing the cell bodies of incoming sensory-nerve fibers.
{{Trigeminal nerve | state = expanded}} will show the template expanded, i.e. fully visible. This template is a navigation box relating to anatomy that provides links to related topics. When editing the links in this template: Include a single link to the article. Do not add: synonyms or information about the structure itself (eg nerve or ...
Hence, the TVS has provided a template for migraine pathophysiology and target for drug discovery. The history of some discoveries re the TV System are summarised in Ashina, et al. [ 13 ] The Brain Prize for 2021 was awarded to 4 investigators studying the trigeminovascular system and its implications for migraine pathophysiology and treatments.
The trigeminal ganglion contains cell bodies of the pseudo-unipolar sensory neurons of the trigeminal nerve which extend their axons both distally/peripherally into the three divisions of the trigeminal nerve on the one end, and proximally/centrally to the brainstem on the other end; the trigeminal root extends from the trigeminal ganglion to the ventrolateral aspect of the pons.
The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla, and into the upper cervical spinal cord. The nucleus is divided into three parts, from rostral to caudal (top to bottom in humans): The mesencephalic nucleus; The principal sensory nucleus
The first-order neurons from the trigeminal ganglion enter the pons and synapse in the principal (chief sensory) nucleus or spinal trigeminal nucleus.Axons of the second-order neurons cross the midline and terminate in the ventral posteromedial nucleus of the contralateral thalamus (as opposed to the ventral posterolateral nucleus, as in the dorsal column medial lemniscus (DCML) system).
The trigeminal lemniscus contains two main divisions: The ventral trigeminal tract - consists of second-order axons from the spinal trigeminal nucleus. These fibers cross the midline and ascend to the contralateral thalamus. The dorsal trigeminal tract - consists of second-order axons from the principal sensory nucleus of trigeminal nerve ...
The spinal trigeminal nucleus is a nucleus in the medulla that receives information about deep/crude touch, pain, and temperature from the ipsilateral face. In addition to the trigeminal nerve (CN V), the facial (CN VII), glossopharyngeal (CN IX), and vagus nerves (CN X) also convey pain information from their areas to the spinal trigeminal nucleus. [1]