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Dofetilide is a class III antiarrhythmic agent. [2] It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 μg of dofetilide. It is not available in Europe [3] or Australia. [4]
Dofetilide blocks only the rapid K channels; this means that at higher heart rates, when there is increased involvement of the slow K channels, dofetilide has less of an action potential-prolonging effect. Sotalol is indicated for the treatment of atrial or ventricular tachyarrhythmias, and AV re-entrant arrhythmias.
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Dofetilide. PubMed provides review articles from the past five years (limit to free review articles)
Dofetilide; Dronedarone; E-4031; Ibutilide; Sotalol; Vernakalant; K + channel blocker. Sotalol is also a beta blocker [5] Amiodarone has mostly Class III activity, but also I, II, & IV activity [6] Prevent paroxysmal atrial fibrillation [7] and haemodynamically stable ventricular tachycardia [8] (amiodarone) Treat atrial flutter and atrial ...
Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
If atrial fibrillation with pre-excitation occurs, treatment options include procainamide, flecainide, propafenone, dofetilide, and ibutilide, since these medications slow conduction in the accessory pathway causing the tachycardia and should be administered before considering electrical cardioversion.
dofetilide (Tikosyn) Antihistamines: terfenadine (Seldane) (off the market) diphenhydramine (partially) astemizole (off the market) Calcium channel antagonists: felodipine (Plendil) nicardipine (Cardene) nifedipine (Procardia) nimodipine (Nimotop) nisoldipine (Sular) isradipine (DynaCirc) Statins (HMG-CoA reductase inhibitors) simvastatin (Zocor)
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
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related to: dofetilide wikipedia- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
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