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  2. Dofetilide - Wikipedia

    en.wikipedia.org/wiki/Dofetilide

    Dofetilide is a class III antiarrhythmic agent. [2] It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 μg of dofetilide. It is not available in Europe [3] or Australia. [4]

  3. Potassium channel blocker - Wikipedia

    en.wikipedia.org/wiki/Potassium_channel_blocker

    Dofetilide blocks only the rapid K channels; this means that at higher heart rates, when there is increased involvement of the slow K channels, dofetilide has less of an action potential-prolonging effect. Sotalol is indicated for the treatment of atrial or ventricular tachyarrhythmias, and AV re-entrant arrhythmias.

  4. List of withdrawn drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_withdrawn_drugs

    Dofetilide: 2004 Germany Drug interactions, prolonged QT. [14] Drotrecogin alfa (Xigris) 2011 Worldwide Lack of efficacy as shown by PROWESS-SHOCK study [19] [20] [21] Ebrotidine: 1998 Spain Hepatotoxicity. [3] Efalizumab (Raptiva) 2009 Germany Withdrawn because of increased risk of progressive multifocal leukoencephalopathy [14] Encainide ...

  5. Antiarrhythmic agent - Wikipedia

    en.wikipedia.org/wiki/Antiarrhythmic_agent

    Dofetilide; Dronedarone; E-4031; Ibutilide; Sotalol; Vernakalant; K + channel blocker. Sotalol is also a beta blocker [5] Amiodarone has mostly Class III activity, but also I, II, & IV activity [6] Prevent paroxysmal atrial fibrillation [7] and haemodynamically stable ventricular tachycardia [8] (amiodarone) Treat atrial flutter and atrial ...

  6. List of cardiac pharmaceutical agents - Wikipedia

    en.wikipedia.org/wiki/List_of_cardiac...

    Class of medications that are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic nervous system.

  7. Ebstein's anomaly - Wikipedia

    en.wikipedia.org/wiki/Ebstein's_anomaly

    If atrial fibrillation with pre-excitation occurs, treatment options include procainamide, flecainide, propafenone, dofetilide, and ibutilide, since these medications slow conduction in the accessory pathway causing the tachycardia and should be administered before considering electrical cardioversion.

  8. Talk:Dofetilide - Wikipedia

    en.wikipedia.org/wiki/Talk:Dofetilide

    Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Dofetilide. PubMed provides review articles from the past five years (limit to free review articles)

  9. Bictegravir - Wikipedia

    en.wikipedia.org/wiki/Bictegravir

    Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]

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